Guardiola was speaking after Manchester City's 3-1 UEFA Champions League win over Red Star Belgrade on Tuesday night.
Key midfielder Bernardo Silva was taken off in the first half with what looked like a muscle injury expected to rule him out for a few weeks.
Silva joins a long injury list that includes Kevin De Bruyne, John Stones, Mateo Kovacic, and Jack Grealish.
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Guardiola laments City's injury troubles
"We have five important players injured. Sustaining that for a long time will be difficult but it is what it is.
“We cannot have 35 players because that will be chaos for the clubs and go bankrupt.
“Unfortunately it’s a long time for Kevin, John didn’t play, maybe Kova is coming back, Jack has a week or 10 days,” Guardiola told the club’s official website.
The City boss added: “We are in trouble but I’m not going to say ‘oh, we have a lot of injuries’. It is what it is.”